摘要
放射免疫显象时的肠道放射性常导致腹部显像结果判断的困难。为了研究肠道放射性来源机理，将大鼠分为胆总管切断组和对照组，在注射１１１铟标记的ＺＭＥ－０ｌ８（抗黑色素瘤，ＩｇＧ２ａ）后，肠道放射性在两组间无显著性差异。说明单克隆抗体ＺＭＥ－０ｌ８直接被肠壁吸收而不通过胆道排泄；在注射１１１铟标记的ＺＣＥ－０２５后，胆总管切断组肠道放射性较对照组低３０％，说明单克隆抗体ＺＣＥ－０２５（抗癌胚抗原，Ｉｇ１）既被肠壁直接吸收，又通过胆道排泄。
owel radioactivity may be seen followingthe administration of some 111 In
or 99m TcMcAbs and consequently interfere with the in-terpretation of abdominal imagcs. In
order toinvestigate the mechanism by which McAbsenter the gut, groups of rats underwent
bileduet ligation while others served as sham op-erated controls. Following i. v. injection of
111In ZME - 018 (IgG 2a. anti - melanomaMcAb), there was no significant differencebetween the
corzibined intestinal wall and fecaliadioactivity in the control rats and the bileduet .ligated
group, suggesting that this McAbwas transported directly across the bowelwall. Following i. v.
injection of 111 In ZCE-025 (IgG1, anti - carcinoembryonic antigenMcAb), there was a 30%
decrease in gut ra-dioactivityin the bile duct ligated rats com-pared to the control group,
suggesting thatboth direct transport across the bowel walland hepatobiliary excretion
contributed tobowel radioactivity
出处
《铁道医学》
1994年第6期321-323,共3页
Railway Medical Journal
