摘要
采用家兔法和鲎试剂法抽检临床４８２批大输液的热原，并对４０批（８０００瓶）大输液的临床热原反应作追踪调查。结果表明大输液产品质量是临床热原反应的主要原因。经比较认为鲎试剂法检测热原的准确度和灵敏度较家兔法为高。提出家兔法检测热原的新控制标准为三只兔升温总和＜１℃。
The pyrogen in random clinical intravenous infusion of 482 batcheswas detected by rabbit and limulus test,respectively. And the investigation of clinicalpyrogen reaction in intravenous infusion of 40 batches,a total of 8000 bottles,was fol-lowed up. The results have shown that the quality of intravenous infusion preparation ismain reason causing clinical pyrogen reaction and that the limulus test is more accurateand sensitive than rabbits pyrogen test.A new control standard that the summation ofthree rabbit′s temperature increased is equal or below 1℃C, for detected pyrogen in in-travenous infusion by rabbits pyrogen test is presented
出处
《泰山医学院学报》
1994年第3期170-172,共3页
Journal of Taishan Medical College
关键词
输液疗法
兔热原试验
鲎试验
热原
大输液
rabbit pyrogen test
limulus test
pyrogen
intravenous infusionpreparation
