摘要
报告分析20例血液病染色体检查结果,MDS9例,白血病11例。MDS 组染色体畸变率与白血病组一样明显高于正常人,并有多样化和非随机性的特点。异常核型检出6例,MDS1例46,XX,t(8;21)(q^(24);q^(22)),白血病5例为46,XY/45,X-Y;45,XX,-5及46,XY,ph3例。表明 MDS 染色体改变已具备了恶性肿瘤的特点、还可有克隆性异常改变。
Cytogenitic studies indicated that chromosome abnormality of patients withMDS had been associated mith leukemia.The result of the chromosome examinationin 20 cases was analysed,9 MDS and 11 leukemia.The chromosome aberration ratesof the MDS group and the leukemia group were much higher than that of the com-pared group,and then the chromosome abnormality of MDS was multiform and non-random.The abnormal karyotype was found in six of the twenty cases,one MDS casewith 46,XX,t (8;21) (q^(24);q^(22);),and five cases leukemia with 46,XY/45,X,-Y;45,XX,-5 and three of 46,XY,ph.It was shown that the chromosome abnormalityin MDS might be consistent with cancer characteristics and the clonal chromosomeabnormality as well.The chromosome examination of leukemia was of value to thediagnosis,treatment and prediction of the disease,especially much more valuable tothe research in the cause of leukemia,the location of oncogene and their relationship.
出处
《天津医药》
CAS
1989年第6期326-329,共4页
Tianjin Medical Journal
