摘要
本文用电子显微镜，ＥＬＩＳＡ法、Ｋｉｂｒｉｃｋ法、Ｉｓｏｊｉｍａ法研究了经输精管向附睾方向注射小剂量（０．３～０．５ｍｌ／侧）鱼肝油酸钠后，人射出精子超微结构和血清抗精抗体的变化。结果表明：１．射出精子卷尾畸形增多，精液内有巨噬细胞和淋巴细胞，并发现巨噬细胞吞噬精子现象；２．血清中抗精抗体Ｋｉｂｒｉｃｋ法阳性率为２５％，Ｉｓｏｊｉｍａ法阳性率为８．３％。因此可见，经输精管向附睾方向注射０．３～０．５ｍｌ／侧鱼肝油酸钠的抗生育作用机制主要是注入到附睾局部的鱼肝油酸钠可破坏附睾内精子及附睾上皮功能从而诱发局部免疫反应所造成。因此，可以认为此法是一种安全、有效、简便的非手术性男子节育方法。
The ultrastructure of sperm and serum antisperm antibody after injection small dosge (0. 3 0. 5 ml/side) of sodium morrhuate via van deferens into epididymis were examined by electric microscope, Kibrick's test, lsojima's test in this paper. The results showed: 1. There are sperm abnormality of coiled tail and macrophage, lymphocyte in semen. 2. Kibrick's positive rate is 25 %;Isojima's positive rate is 8. 3%. Its machanism on antifertility may be effect the structure and functions of epididymis yis multiple factors and develop local immune reaction. Thenefore, It is a simple and nonsurgical method for male fertility control.
出处
《生殖与避孕》
CAS
CSCD
北大核心
1994年第4期306-308,共3页
Reproduction and Contraception
关键词
抗生育
鱼肝油酸钠
附睾
抗精抗体
Antifertility, Sodium morrhuate, Epididymis, Antisperm antibody
