摘要
本文为了进一步验证丙酸睾丸酮（简称丙睾）在药物抗早孕中的作用，使用随机双盲法，将１５１例早孕妇女分为两组，丙睾＋１６，１６－双甲基－反式△２－ＰＧＥ１（简称ＯＮＯ８０２）组，肌注丙睾３００ｍｇ后用ＯＮＯ８０２阴道检１ｍｇ，每６ｈ重复一次，总量为４ｍｇ。对照组使用外观完全相同的安慰剂代替丙睾，ＯＲＯ８０２的用法相同。结果示丙睾＋ＯＮＯ８０２组完全流产，不全流产和失败率分别为７３．３％、１２．０％和１４．７％；对照组为５２．６％、１９．７％和２７．６％（Ｐ＜０．０５）。ＯＮＯ８０２的平均用量分２．３８±１．１９ｍｇ和２．８６±１．１１ｍｇ（Ｐ＜０．０１）。两组引～流时间各为７．Ｚｈ及８．６ｈ，平均流血时间各为１４及１７９。说明丙睾确实能减少前列腺素药物的用量和提高其抗早孕的临床效果。
The study was to compare the termination of pregnancy within 49 days amenorrhea by intravaginal administration of 16,16-dimethyl trans A2PGE1 methyleager (ONO802) 1 mg per suppository every 6 hours within a maximum of four doses Pretreated by testosterone propionate 100 mg daily intramuscularly for 3days to that of ONO802 pretreated by placeho injections.The number of patients in Study group and the control group were 75 and 76respectively. Their frequencies of complete abortion, incomplete abortion andfailures of treatment were 73. 3%, 12 .0%, 14. 7% and 52 .6% 19. 7%,27. 6% respectively with significant difference (P<0 .05). The mean dosages per patient usedwere 2. 38± 1. 19mg in the study group and 2. 86+1. 11 mg in the control group,giving a very significant difference (P<0.01). The induetion to abortion inter-vals of the study group and the eontrol group were 7.2 hours and 8.6 hours, andthe mean durations of bleeding in eaeh group were 14 and 17 days. The sideeffects were mainy vomiting and diarrhea, but mild and acceptable. No obviousPlelvi infection or other oomlication was found. The hemoglobin value did notdecrease during the two weeks observation periods in both groups.The first menstruation reappeared in an average of 36. 5 and 30. 5 days in thestudy group and in the control group after treatment, lasted for 6 days each.Themenstrual blood loss eomparable with their own menstrual .flow were 61. 8% and60.0%, but 14.6% and 25.0% heavier, 23.6% and 15.0% less than their ownblood flow in the studied group and control group respectively.
出处
《生殖与避孕》
CAS
CSCD
北大核心
1994年第1期29-33,共5页
Reproduction and Contraception
关键词
ONO802
丙酸睾丸酮
抗早孕
ONO802, Testosterone propionate, Termination of early pregnancy
