摘要
转铁蛋白为一类金属结合一转运糖蛋白，经典的理论阐明其在体内的主要作用是运送铁离子到各器官与组织。根据近两年的研究，转铁蛋白除了转运铁离子的作用外，还具有局部调节卵巢功能的作用，即能抑制ＦＳＨ诱导大鼠及人卵泡颗粒细胞的功能性分化。转铁蛋白抑制ＦＳＨ诱导卵泡颗粒细胞分化的主要机理是：（１）转铁蛋白部分地抑制ＦＳＨ与卵泡颗细胞上的受体结合，减少细胞内ＣＡＭＰ生成，进而抑制了ＦＳＨ受体的维持表达。（２）转铁蛋白对抑制素及雌二醇生成的影响还存在着ｃＡＭＰ以后（或以外）的作用部位。（３）转铁蛋白的作用机理不涉及影响蛋白激酶Ｃ系统的活性及钙离子释放过程，且与颗粒细胞的“增殖一分化相逆机理”无关。
Transferrins are a class of related metal-binding transport glycoproteins for transporting iron to various organs and tissues of the body.In recent years,it has been reported that the transferrin can play an important role in the local regulation of ovarianfunction,apart from its iron-binding characteristic.Transferrin could attenuate FSHinduced differentiation of rat and human granulosa cells and its mechanisms were considered as follows:(1)Transferrins partially blocked the binding of FSH with its receptors on granulosa cells and reduced the formation of intracellular cAMP,and thereforeinhibited the expression of FSH receptors.(2)Acting sites beyond cAMP formation alsoexisted for the inhibitory effect of transferrin on inhibin and estradiol production.(3)The inhibitory effect of transferrin seemed not to be involved in the changes of proteinkinase C activity,the calcium release and 'proliferation-differentiation reversed mechanism'in granulosa cells.
出处
《生理学报》
CAS
CSCD
北大核心
1994年第3期209-216,共8页
Acta Physiologica Sinica
关键词
转铁蛋白
卵泡颗粒细胞
促滤泡素
transferrin
granulosa cells
differentiation
FSH
estradioll progesterone
inhibin
