摘要
用Ｙ型迷宫箱测试小鼠空间分辨能力，结果：ｐｏ －硒化卡拉胶（ －ｓｅｌｅｎｏｃａｒｒａｇｅｅ－ｎａｎ， －ＳｅＣ）１８０ｍｇ／ｋｇ及１０８ｍｇ／ｋｇ（ｑｄ×１４ｄ）能增强正常小鼠的学习能力，提高学习成绩；ｐｏ －ＳｅＣ１８０、１０８及６４ｍｇ／ｋｇ（ｑｄ×１４）对东莨菪碱（ｉｐ４ｍｇ／ｋｇ）所致小鼠学习障碍均有拮抗作用；ｐｏ －ＳｅＣ１８０ｍｇ／ｋｇ（ｑｄ×１４）对东莨菪碱（ｉｐ５ｍｇ／ｋｇ）所致小鼠记忆保持障碍有改善作用。以上表明 －ＳｅＣ对脑的学习功能有促进作用，并能拮抗药物引起的学习与记忆功能的损害，改善大脑功能．
By using the Y-maze method,the effect of -selenocarrageenan(μ-SeC) on spatial discrimination learning and memory retention in mice were studied.The results were as follows:①-SeC(po 180 or 108 mg/kg, qd×14d) given before testing raised discrimination learning ability in mice;②-SeC(po 180, 108 or 64.8mg/kg,qd×14d) improved the discrimination learning impairment induced by scopolamine(ip 4 mg/kg);③-SeC(po 180 mg/kg, qd×14d) improved the memory retention impairment indnced by scopolamine. It was shown that SeC exerted the improved effects on the experimental cognitive impairment in mice.
出处
《上海医科大学学报》
CSCD
1994年第6期443-446,共4页
Journal of Fudan University(Medical Science)
关键词
硒化卡拉胶
东莨菪碱
小鼠
分辨学习
记忆保持
selenocarrageenan
scopolamine
discrimination learning
memory retention
mice
