摘要
麻黄碱（０．９９～３３０ｕｍｏｌ／Ｌ）使离体大鼠肛凡肌收缩呈剂量依赖关系．酚妥拉明１００ｎｍｏｌ／Ｌ，利血平予处理（５ｍｇ／ｋｇ，ｉｐ）均使麻黄碱的作用减弱，可卡因１０ｕｍｏｌ／Ｌ则无影响。低钙Ｋ－Ｈ液中，麻黄碱引起肛尾肌和门静脉收缩减弱，无钙Ｋ－Ｈ液中收缩消失。表明麻黄碱对肛尾肌、门静脉的作用与直接和（或）间接兴奋ａ肾上腺素能受体有关，亦与细胞外钙离子浓度有关。
The contractile effect of ephedrine(0.99～330 μmol/L)on rat
anococcygeus muscles showed typical dose-dependent relationship.When the concentration of
ephedrine was higher than 330 μmol/L,this contratile action was depressed.The
concentration-response curve of ephedrine was shifted to the right by either phentolamine or
reserpine-pretreatment.Cocaine does not affect contractile effect of ephedrine.The maximal
contractile effect of ephedrine was depressed by a low concentration of calcium ions.In the
calcium-free solution the contractile effect of ephedrine on anococcygeus muscles and portal
vein strips of rat disppeared.The results suggest that contractile effect of ephedine on rat
anococcygeus muscles may relate toa direct and/or indirect stimulating action on
adrenoreceptors,and that it may also relate to the extracellular calcium ions.
出处
《内蒙古医学院学报》
1994年第2期100-103,共4页
Acta Academiae Medicinae Neimongol
关键词
麻黄碱
α肾上腺素能
受体
钙
肌肉
收缩
ephedrine,α-adrenoceptor
calcium ions
muscles contractile
rats
