摘要
对１０１例原发性肝癌（ＰＨＣ）同步检测几项标记，其阳性率为ＡＦＰ７６．２％，ＧＧＴⅡ８５．１％，ＡＬＰⅠ２４．８％，ＡＡＴ７５．１％。与肝硬化、慢性肝炎、肝良性占位性病变、肝外肿瘤、正常人等组比较，差异有显著性。假阳性率以肝硬化用组高，分别为ＡＦＰ１５．０％，ＧＧＴⅡ１０．０％，ＡＬＰⅠ３．３％，ＡＡＴ２６．７％。在ＡＦＰ＜５０ｎｇ／ｍｌ２４例中，ＧＧＴⅡ阳性率为７０．８％，ＡＬＰⅠ为１６．７％，ＡＡＴ为６６．７％。本文结果显示、ＧＧＴⅡ诊断ＰＨＣ敏感性、特异性均佳，优于ＡＦＰ、ＡＬＰⅠＩ及ＡＡＴ。ＧＧＴⅡ与ＡＦＰ互补诊断可提高阳性率。
The simultaneous determination of serum hepatoma-speeifle r-glutamyltransferase isoenzyme Ⅱ(GGT Ⅱ) and alkaline phosphatase isoenzyme Ⅰ(ALP Ⅰ), α1 antitrysin (AAT)and α-fetoprotein (AFP) was carried out in 101 cases of primary hepatic cancer (PHC), 60 liver cirrhosis, 66 chronic hepalitis, 14 benign occupying lesion of liver, 13 cancer other than PHC and 100 normal subjects. The conclusions were:(1) The positive rates for CGTⅡ, ALPⅠ,AAT and AFP in patients with PHC were 85.1%,24.8%, 75.1%and 76. 2%respectively. (2) GGTⅡ,ALP Ⅰand AAT all had no relations with AFP in cases of PHC; (3)The result of combined assay of GGTⅡ,ALPⅠ,AAT and AFP in serum of PHC showed that the sensitivity of at least one positive marker was as high as 98% and the specificity of at least two positive markers was 94. 2%;(4) Of 24 PHC patients with AFP< 50ng/ ml,22(91.7%)were diagnosed with simultaneous determination of GGT Ⅱ, ALP Ⅰand AAT.The results above suggest that the determination, especlally simutancous determination, of GGTⅡ,ALP Ⅰ and AAT, is useful in the diagnosis of PHC with negative AFP or slightly inereased AFP.
出处
《南通医学院学报》
1994年第2期153-157,共5页
ACTA Academiae Medicinae Nantong
关键词
肝肿瘤
肝癌标记
AFP
GGTⅡ
诊断
primary hepatic cancer
r-glutamyltransferase isoenzymeⅡ
alkaline phosphatase isoenzyme Ⅰ
α_1antitrypsin
α-fetoprotein
