摘要
本实验收集３１例肝细胞癌手术切除标本和５例穿刺活检标本，采用免疫组织化学方法研究肝癌组织中纤维连接蛋白（ＦＮ）的分布特点及其对肿瘤生物学行为的影响，结果发现：肝癌组织中ＦＮ主要分布于肝窦壁、基质、细胞周边及腺管周围等部位，ＦＮ的阳性表达随癌组织分化程度的降低而降低，表明了ＦＮ的表达与否与肿瘤细胞的分化程度显著相关，影响了肝细胞癌的预后。
This article presents the results of observation on the distribution and the biological significance of Fibronectin(FN) in 36(31 surgical specimens and 5 biopsy) cases of Hepatocellullar Carcinoma(HCC) by immunohistochemical technique. The results show that Fibronectin was localized either sinusoidal, stromal, pericellular or periglandular and correlated with histological grade. So these suggested that the presence of FN was correlated with well-differentiated tumours,correlating with the better prognosis.
出处
《南通医学院学报》
1994年第1期5-7,共3页
ACTA Academiae Medicinae Nantong
关键词
纤维连接素
肝细胞癌
免疫组化
fibronectin
immuohistochemical
hepatocellular carcinoma
