摘要
定了３２例急性肾小球肾炎患儿血清补体溶解免疫复合物（ＣＭＳＣ）和抑制免疫复合物沉淀能力（ＩＣＰＩＣ）。结果发现急性期患儿血清ＣＭＳＣ和ＩＣＰＩＣ明显下降，病程第７周恢复正常。相关分析表明血清ＣＭＳＣ、ＩＣＰＩＣ与血清ＣＨ５０、Ｃ３和Ｃ４呈明显正相关，与循环免疫复合物无线性关系。该研究提示急性肾炎存在血清ＣＭＳＣ和ＩＣＰＩＣ下降，其可能与急性肾炎的发病机制有关。
In this study serum cpmplement mediated immune complex solubilizing capacity(CMSC)and immune complement precipitation capacity(ICPIC)of 32 children with acute glomerulonephritis(AGN)were measured.The data showed that the level of serum CMSC and ICPIC was markedly decreased in acute phase and returned to normal in the 7th week after onset of disease.Correlation analysis revealed that there were positive correlation between the level of serum CMSC and ICPIC and the serum concentration of CH50,C3,C4,but no linear correlation between the level of serum CMSC and ICPIC and the amount of CIC.These results suggest that the declined serum CMSC and ICPIC in AGN may be associ ated with the pathogenesis of AGN.
关键词
肾小球肾炎
免疫复合物病
补体
Glomerulonephritis,acute
complement
immune complex disease
complement mediated immune complex solubilizing capacity
immune complex precipitation inhibition capacity
