摘要
用20例扩张型心肌病患者血清中抗心肌线粒体ADP/ATP载体抗体进行心肌细胞毒性试验,发现18例患者血清引起心肌细胞毒性损害,且具有钙依赖性,异搏停明显地抑制这种细胞毒性反应,使细胞死亡率均值从71.61%±7.67%降到42.56%±6.54%(P<0.01),该细胞毒性反应与对照组比较具有显著性差异.本研究提示抗心肌线粒体ADP/ATP载体抗体作用于心肌细胞膜钙通道,引起细胞钙超负荷和细胞死亡,是扩张型心肌病的发病机理之一.
The myocardial cytotoxic test was performed using the antibodies against the mito-chondrial ADP/ATP carrier in 20 patients with dilated cardiomyopathy. The sera induced myocardial cytotoxicity in 18 out of the 20 patients. The cytotoxicity was calcium-dependent and was-markedly inhibited by verapamil ,the mean cell mortality(MCM) was reduced from 71. 61%±7. 67 % to 42.56% ±6. 54%(P<0.01), compared with the MCM of control group and had significant difference. The above findings suggest that the antibodies against the ADP/ATP carrier bind to the calcium channel of the myocardial cell membrane, induce intracellular calcium overload and cell death. It may be one of the pathogenesis in dilated cardiomyopathy.
出处
《临床心血管病杂志》
CAS
CSCD
北大核心
1994年第2期80-82,共3页
Journal of Clinical Cardiology
