摘要
应用免疫组化和银染技术检测胆囊癌组织中ＥＲ和ＰＲ的表达及Ａｇ－ＮＯＲ数目。４０例胆囊癌ＥＲ和ＰＲ阳性率分别为６０％和５２．５％，两者呈正相关，Ａｇ－ＮＯＲ分布表现为核仁型和颗粒型；高分化腺癌中ＥＲ，ＰＲ阳性率高于低分化腺癌；高分化腺癌Ａｇ－ＮＯＲ均数明显低于低分化腺癌；高分化腺癌和ＥＲ，ＰＲ阳性者主要表现为核仁型，反之为颗粒型。结果提示，ＥＲ，ＰＲ和Ａｇ－ＮＯＲ可能是反映胆囊癌生物学行为的重要标记物。
he expressions of ER, PR and counts of Ag-NOR
were studied by immunohis-tochemistry aiid argyrophilic staining in 40 cases of gallbladder
carcinoma. The positive ratesof ER,PR were 60%,and 52.5%respectively;the positive rates of
ER ,PR were higher inwell-differentiated adenocarcinomas,and the mean of Ag-NOR was lower
in the carcinoma ofwell-differentiated,ER(+)and/or PR(+);Ag-Nor showed nucleolar type in large
part ofwell-differentiated and ER(+)and ER (+) and/or PR (+)carcinomas,and a majority ofother
kinds of carcinomas showed granular type;closed correlation might exist among themean and
types of Ag-NOR and the expression of ER,and PR. These results suggest thatER,PR and
Ag-NOR might be good markers for reflecting the biological behavior of gall-bladder carcinoma.
出处
《湖南医科大学学报》
CSCD
1994年第4期291-294,共4页
Bulletin of Hunan Medical University
关键词
胆囊肿瘤
癌
受体
雌激素
黄体酮
AGNOR染色
gallbladder
neoplasms
receptor,estrogenlrecoptor,progesterone
immunohistochemistry
nucleolar
organizer region
