摘要
通过对４０例慢性结肠炎患者及３０例健康人的对比观察，发现任性结肠炎患者血中丙二醛（ＭＤＡ）含量升高，谷胱甘肽过氧化物酶（ＧＳＨＰＸ）、红细胞过氧化氢酶（ＣＡＴ）、超氧化物歧化酶（ＳＯＤ）、维生素Ｃ（ＶＣ）、维生素Ｅ（ＶＥ）水平降低，呈负相关性，运用中药蒲败灌肠液治疗后ＭＤＡ明显下降。而ＧＳＨＰＸ、ＣＡＴ、ＳＯＤ、ｖｃ，ＶＥ水平较治疗前升高。由此推论自由基损伤是慢性结肠炎普遍的发病机理，抗自由基损伤是清热解毒化湿法治疗慢性结肠炎的机理之一。
A clinical trial to eveluate the method of clearing away heat and toxic materials and eliminating the dampness-evil with Chinese medlcal herbs 'puhai Guanchang Ye' in treating chronic celitis patients was conducted. Forty patients with chronic colitis were compared with 30 healthy persons ascontrol.The results showed that patients’s serum levels of Malondialdehyde(MDA) increased,Glutathione peroxidase (GSHPX), Catalase (CAT),SuperoxideDismutese (SOD),Vitaminum E(VE),Vitaminum C (VC)dropped down. After treatment with Pubai Guanchang Ye, the activity of MDA revealedsignificant improvement,the levels of GSHPX,CAT ,SOD,VE,VD in seruminereased. It is considered that free radical damage is a general mechanismof chronic colitis,and anti-free radical damage with clearing away heat and toxic materials and eliminating the dampness-evil may play an important roleon treatment.
关键词
结肠炎
中医药疗法
蒲败灌肠液
氧自由基
COLITIS/TCM ther @PUBAI GUANCHANG YE/ther use ANTIPYRETIC-DETOXICATE DRUGS/THER USE DAMPNESS-KISPELLING AGENTS AND DIURETICS/THER USE @FREE RADICAL
