摘要
用组织化学及免疫组织化学方法检测２２例肝细胞不典型增生（ＬＣＤ）的γ－ＧＴ酶、甲胎蛋白（ＡＦＰ）、癌胚抗原（ＣＥＡ）的表达情况。其中１７例同时应用显微分光光度计检测其ＤＮＡ含量，以探讨其与上述３种肿瘤标志表达情况的关系。结果显示：ＬＣＤ的肿瘤标志表达既不同于非不典型增生之肝细胞也不同于肝细胞癌，其ＤＮＡ含量均值及倍体分布介于癌与非不典型增生肝细胞之间（ｐ＜０．０５～０．０１）。ＤＮＡ的改变与肿瘤标志的表达存在一定的内在联系。提示ＬＣＤ是一类轻重不同的增生性病变，其中含非整倍体细胞较多的或许是肝细胞癌的癌前病变。
The expressions of γ-glutamyl transpeptidases(γ-GT),alphafetaprotein (AFP)and carcinoemybryonic antigen(CEA) were studied histochemically in 22 cases of liver celldysplasia(LCD).The nuclear DNA content of the cells wasmeasured by OPTON Ⅲmicrospectrophotometry in 17 cases of LCD, The results showed that the three tumor markersin LCD were neither like those in HCC nor like thosein non-dysplastic liver cells. The meanDNA content and the distribution of the euploids of LCD lay between those of HCC and nonliver cell dysplasia(P< 0.05～0.01)These results suggest that LCD is a group of proliferatingcells,and those with rehtively high ratio ofaneuploid cells might be premalignant.
出处
《广西医科大学学报》
CAS
1994年第1期38-41,共4页
Journal of Guangxi Medical University
基金
国家自然基金
关键词
肝细胞
增生
谷氨酰转肽酶
liver cell dysplasia
γ-glutamyl transpeptidases
alpha-fetoprotein
carcinoembryonic antigen
DNA
