摘要
作者采用脂肪乳剂对家兔连续灌胃2w,分析比较了灌胃前后血清甘油三酯(TG)、总胆固醇(TC)、载脂蛋自B(ApoB)之变化和血浆血栓素(TX2)和前列腺素16─Keto─PGF1α之变化。结果发现:TC、TG、ApoB、TXB2均明显上升,有极显著性差异(P<0.01);6-Ket-PGF1α明显下降,具有极显著性差异(P<0.01)。其中,Tc含量较灌胃前增力15.4倍,TG较灌胃前增加3.3涪,完全符合食饮性动物高脂血症模型的特点。作者采用上述模型观察了灵芝对其TC、TG、ApoB、TXB2、d-Keto-PGF1α之影响。结果发现:用灵芝制剂对高脂血症家兔行灌胃治疗,TC下降率为3.118%±2.89%,TG下降卒为62.99±12.18,与对照组有显著差异(P<0.05)。ApoB有一定程度降低。
The changes of serum total TG,TC,ApoB and TxB2,6-Keto-PGF12 were studied in the rabbits before and after two weeks sausage,The rusults showed that TG,TC,TXB2 all rose apparently and the difference was statistically significant(P<0.01).The facts that serum TG Values increased 15.4 times and TC 3.3 times were denfical to the model of hyperlipemia.
关键词
高血脂病
动物模型
灵芝
药理
Hyperlipemia TC TG TXB2 APoB.d-Keto-PGF12