摘要
本文报道用Ａｍｅｓ试验、微核试验和体外培养中国仓鼠肺细胞（ＣＨＬｃｅｌｌｓ）染色体畸变试验检测氟康唑（ＦＣＺ）致突变作用的结果：ＦＣＺ浓度达５００μｇ／皿，不论加与不加Ｓ９代谢活化系统，对各菌株均无诱发回复突变作用；２００ｍｇ／ｋｇ腹腔注射，未引起小鼠骨髓多染红细胞微核率增加；在２００ｇ／ｍｌ浓度下，不论是否经Ｓ９代谢活化，均未导致ＣＨＬ细胞染色体畸变。
Ames test,micronucleous test on mice and chromosome aberration test on Chinese
hamster lung cells( CHL cells)in vitro were used to detect the mutagenicity of fluconazole(FCZ).
The results showed that FCZ induced no mutagenic effects in Ames up to 500 μg per dish on
4strains with or without the presence of S9 metabolic activiaton. FCZ did notincrease the
incidence of micronucleated polychromatic erythrocytes in bone marrowin mice efter ip
administration with 200 mg/kg. FCZ in a concentration of200μg/ml,with or without S9 mix failed
to induce chromosomal aberration onCHL cells in vitro.
出处
《癌变．畸变．突变》
CAS
CSCD
1994年第6期60-63,共4页
Carcinogenesis,Teratogenesis & Mutagenesis
关键词
氟康唑
AMES试验
微核试验
抗真菌药
致突变
fluconazoles Ames test
micronucleous test
CHL cells
chromosomalaberration test
