摘要
Dystrophin基因第50和51号内含子是基因缺失热点之一。对其核昔酸顺序分析表明在50号内含子的305bp和51号内含子的402bp中的存在多个重复顺序,AT含量分别为73%和70%。讨论了Dystrophin基因可能缺失的机制,提出内含子中at富集区的重复顺序可能与DNA断裂有关。
The introns 50 and 51 of dystrophin gene are one of the deletion hot spot in dystrophin gene. The results of sequence showed that there were many repetitive sequences between 305 bp of intron 50 and 402 bp of intron 51, in which the AT contents of the introns 50 and 51 were 73% and 70%, respectively. The DNA deletion mechanism (homologous recombination)was discussed. We suggest that the repetitive sequences in the intron AT-richregions be related to DNA breaking.
出处
《中华医学遗传学杂志》
CAS
CSCD
北大核心
1993年第5期268-270,T018,共4页
Chinese Journal of Medical Genetics
基金
国家自然科学基金
部分863高科技发展基金
