摘要
手术造成大鼠皮肤开放性创伤,电镜下观察伤口愈合过程中结缔组织细胞的变化。结果显示,伤口愈合早期,成纤维细胞及巨噬细胞增多,前者可转变为肌成纤维细胞,并逐渐成为伤口中的主要细胞,而使伤口收缩形成瘢痕。同时可见破纤维细胞吞噬细胞间质。在创伤早期肥大细胞功能活跃,有剧烈的脱颗粒现象,并与成纤维细胞、肌成纤维细胞紧密邻接。说明这些细胞可能相互作用,参与伤口愈合。
Open skin wounds were made in 28 Wistar rats, and the changes of the connective tissue cells were observed by electron microscopy during wound healing. The fibroblasts and macrophages were increased in the early stage, later on the fibroblasts might be transformed into myofibroblasts which became preponderant cells in the wound gradually and led to wound contraction and scar formation. The intercellular substances were phagocytosed by fibroclasts simultaneously. The mast cells were closely apposed to the fibroblasts or myofibroblasts and represented active functions, such as degranulation. Considerably they released the granule contents to the extracellular space and effected the other cells functions. It shows that the cells mentioned above interplay and take part in the wound healing.
出处
《解剖学报》
CAS
CSCD
北大核心
1993年第1期92-96,T015,16,共7页
Acta Anatomica Sinica
关键词
皮肤
创伤
愈合
成纤维细胞
Skin wound healing
Fibroblast
Myofibroblast
Fibroclast
Mast cell
Rat
