摘要
用电位滴定法测定3[N,N-二(羧甲基)氨甲基]-5-(二乙氨甲基)邻苯二酚(代号“8307”,以H_4A表示)的电离常数及Th(Ⅳ)-“8307”配合物的稳定常数。在25±0.2℃,μ=0.1mol/L^(-1)NaClO_4及高纯N_2的条件下,测得pK_1=7.94、pK_2=10.02、pK_3=10.43、pK_4=11.13;lgK_(ThA)=28.10、lg.K_(ThHA+)=21.74、lgK_(Th(H_2A)_2)=31.71、lgK_([Th(H_3A)_2])^(2+)=18.41。数据表明这些配合物的稳定性很高,这与动物试验高促排效果相一致。
The ionization constants of 3-[N, N-bis (oarboxyl methyl) amino methyl]-5-(diethyl amino methyl) oateohol ('8307', H4A) were determined by potentiometric titration with NaOH. pK values are 7.94, 10.02,10.43 and 11.13 at 25±0.2℃ and μ=0.1mol/L NaClO4. The stability contantg of Th (Ⅳ)-'8307' complexes: ThA, ThHA+, Th(H2A)2 and [Th (H3A2) 2]2+ were also determined by potentiometrio titration with NaOH; lg KThA =- 28.10, lgKThHA+ = 21.74, lgKThIH3A)2-31.71 and lg K[Th(H3A)2]2+-18.41 at 25±0.2℃, μ-0.1mol/L NaClO4. The whole experiment waa carried out under nitrogen. The high stability of these complexes agrees fairly well with their removal effect for Th(Ⅳ) ion in animal experiments.
出处
《上海医科大学学报》
CSCD
1989年第1期45-49,共5页
Journal of Fudan University(Medical Science)
基金
国家自然科学基金
1987年国家医药管理总局基金
