摘要
笔者观察了烧伤、冲击伤、烧冲复合伤后大鼠肺泡巨噬细胞产生过氧化氢及肺匀浆和支气管肺泡灌洗液中过氧化氢酶活性的变化。结果表明:伤后各组肺泡巨噬细胞产生过氧化氢增多,复合伤组显著高于烧伤和冲击伤组;肺匀浆与支气管肺泡灌洗液中过氧化氢酶活性下降,复合伤组显著低于烧伤和冲击伤组。提示创伤后肺泡巨噬细胞释放过氧化氢增多及肺组织中过氧化氢酶活性下降在创伤后肺损伤中起一定作用。
In order to clarify the relationship between PAMs and post—trauma lung injury, the H_2O_2 produced by PAMs and catalase activity of bronchoalveolar lavage fluid (BALF) and lung homogenate were measured at hours 6、12、24、48 and 72 after burn、blast injury and burn—blast combined injury in 128 rats, respectively. After trauma, H_2O_2 produced by PAMs was increased compared with PAMs from control lungs, especially in the combined injury groups. The catalase activity of BALF and lung homogenate decreased. The catalase activity in combined injured lungs was the lowest. The results indicated 1. the activation of PAMs might play a role in post—trauma lung injury: 2. the damage of pulmonary antioxidant system after trauma may enhanced the lung injury; 3. the state of PAMs activation and the damage of pulmonary antioxidant system were related to the severity of trauma.
出处
《中华创伤杂志》
CAS
CSCD
北大核心
1993年第4期213-215,共3页
Chinese Journal of Trauma
关键词
肺泡
世噬细胞
过氧化氢酶
烧伤
Pulmonary alveolar macrophage H_2O_2 Blast injury Combined injury
