摘要
从１９８３年１１月－１９８９年８月，采用以顺铂、平阳霉素为主，分别与Ｅｔｏｐｏｓｉｄｅ（Ｖｐ－１６），ＶＣＲ，ＭＭＣ，Ｎｉｔｒｏｃａｐｈａｎｅ（ＡＴ－１２５８）结合的ＤＥＰ、ＤＶＰ、ＤＭＰ、ＤＮＰ４种联合化疗方案，随机分组治疗晚期食管癌１６６例，完全缓解（ＣＲ）１４例（８．４％），部分缓解（ＰＲ）７１例（４２．８％），稍效（ＭＲ）４３例（２５．９％），无效（ＮＲ）３８例（２２．９％）。
From November 1983 to August 1989, 166 patients with advanced esophageal carcinoma were treated with combined chemotherapy including cisplatin (DDP), pingyangmycin (PYM) and other drugs. The patients were divided into 4 groups-DEP (DDP-Etoposidc-PYM). DVP(DDP-VCR-PYM), DMP(DDP-MMC-PYM) and DNP (DDP-Nitrocaphane-PYM). The results showed that 14 eases (8.4%) achieved complete remission (CR), 71 cases (42.8%) partial remission (PR), 43 cases (25.9%) minimal response (MR), 38 cases (22.9%) non-response (NR), The overall response rate(CR+PR+MR) was 77.1%(128/166) and the remission rate (CR+PR) was 51.2% (85/166). The median duration of remission was 2-4 months and median survival 7 months. The remission rate (CR+PR) in DEP (45.4%) and DVP(46.2%) was similar. The remission rate (CR+PR) of DEP and DVP was lower than that of DMP (56.1%) and DNP(57.5%) (P>0.05).The remission rate of various regimens were not significantly different. The toxicity of combined chemotherapy was not severe. 91 cases had Ⅰ°nausea and 44 cases (38 cases with Ⅱ° and 6 cases with Ⅲ°) had vomiting. Mild bone marrow depression occurred 45 cases. Febrile reaction and pigmenta- tion due to pingyangmycin were encountered in 33 cases. Only three patiens had mild neohrotoxicitv.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
1993年第10期747-750,共4页
Chinese Journal of Clinical Oncology
关键词
癌
食管肿瘤
药物疗法
Esophageal carcinoma
Combined chemotherapy
