摘要
采用耳蜗外淋巴灌流技术,观察了外源性催产素(OXT,0.04U/ml)对蜗内直流电位(EP)的影响。发现OXT灌流导致直接记录的EP值(G-EP)有微小下降,但可明显增大EP的负相成分(N-EP,由5mmol/L哇巴因灌流产生)的绝对值。OXT的这种作用可被氯化筒箭毒(dTC)阻断橄榄耳蜗束的传出控制所取消。文中讨论了OXT对EP两种成分影响的可能机制。
Effects of oxytocin (OXT) (0.04U / ml) on enodocochlear potentials(EP) were investigated in guinea pigs by means of perilymph perfusion. It was found that the oxytocin infusion caused a slight decrease in the general value of EP (G-EP) and a significant increase in the absolute value of negative EP (N-EP) which was induced by 5 mmol/ L ouabain. The effect of oxytocin on N-EP could be abolished by d-tubocurarine (dTC), a blocker of efferent nerve of olivo-cochlear bundle. The mechanism underlying the changes in both components of EP induced by oxytocin is discussed.
出处
《中国应用生理学杂志》
CAS
CSCD
1993年第1期13-15,共3页
Chinese Journal of Applied Physiology
基金
国家自然科学基金
关键词
蜗内直流电位
催产素
耳蜗
endocochlear potential
oxytocin
ouabain
d-tubocurarine
