摘要
本文对16例使用庆大霉素(GTM)的志愿患者,在进行血药浓度监测的同时,对体内中分子物质(MMS)和β_2-微球蛋白(β_2-MG)进行测定分析,探讨早期发现肾功能受损的客观指标,结果用药前后MMS 无显著变化(P>0.05)、β_2-MG 则有显著性变化(P<0.05)。本研究提示:对GTM 等氨基糖甙类抗生素的用药病人,在监测血药浓度情况下,监测β_2-MG 变化是有临床意义的。
The in vivo changes of middle molecular substance(MMS)and β_2-microglobin(β_2-MG)were detected in 16 volunteerpatientsinjected with gentamycin(GTM)to make certain the objective index of early kidney disfunction,the drug concentrationsof GTM in blood were also measured in the same time.Significant change had been found on the β_2-MG(P<0.05)yet noton MMS(P>0.05)after GTM was used.The results suggest that it is of clinical significance to detect the β_2-MG change and drug concentration in blood inpatients using aminoglide such as GTM,while the MMS change needs further investigation.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1993年第1期10-12,共3页
Chinese Journal of Hospital Pharmacy
关键词
庆大霉素
中分子物质
微球蛋白
gentamycin
aminoglide
kidney disfunction
middle molecular substance
β_2-microglobin
