摘要
目的:探讨2型糖尿病病人在急性糖代谢过程中脂代谢和肿瘤坏死因子-α(TNF-α)的变化情况，了解胰岛素分泌与其作用的关系。方法:选取32例糖尿病人为研究对象，测定空腹及75 g口服葡萄糖耐量试验(OGTT)餐后2 h的血糖(2 h PG)、胰岛素(INS)、C肽、游离脂肪酸(FFA)、胆固醇(CH)、低密度脂蛋白(LDL)、肿瘤坏死因子(TNF-α)的浓度，并比较它们在糖负荷前后的变化。结果:在急性糖代谢过程中，糖负荷后2 h血中FFA水平较负荷前明显降低，两者比较差异有显著性(P<0.05)；TNFα水平较负荷前也有所下降，但差异无显著性意义(P>0.05)；CH和LDL在糖负荷前后没有变化。结论:2型糖尿病病人血中FFA的变化不是急性糖代谢紊乱的主要影响因素。
To investigate the change of fat metaboli sm and tumor necrosis factor-α(TNF-α) in type-2 diabetes mellitus in acute glucose metabolism and，to analyze the relationship between insulin secretion wi th themMethods:32 individuals of type-2 diabetic patients were studi ed,plasma glucose(PG),insulin(INS),Cpeptide(C-P),free fatty acids(FFA),choles terol(CH),lowdensity lipoproteins(LDL),tumor necrosis factor-α(TNF-α) were analyzed respectively in fasting blood samples and 2 hour plasma samples after 75g oral glucose tolerance test(OGTT)Then compare them in acute glucose met abolismResults:In acute glucose metabolism,following the increase of INS,FFA decreased (P<0.05),and CH,LDL,TNFαhad no change (P>0.05)Conclusion:In type-2 diabetes mellitus,the change of FFA is n ot likely to relateed to acute disorder of glucose metabolism
基金
广西青年科学基金! 桂科青 9631014
