摘要
应用N-ras癌基因产物p21蛋白单克隆抗体,以ABC法检测150例皮肤、软组织肿瘤。结果显示:48例恶性黑素瘤阳性率54.17%,13例先天性巨痣、13例先天性小痣及15例后天性痣阳性率分别为30.77%、15.38%和0%。肿瘤浸润深、异型性较大、核丝分裂指数高的恶性黑素瘤N-ras p21蛋白表达强于相应的组别。其它皮肤、软组织肿瘤的p21蛋白表达率均低。提示恶性黑素瘤的发生及预后与N-ras p21蛋白的过量表达可能有一定关系,其它皮肤、软组织肿瘤与ras基因的激活可能无明显联系。
N-ras oncogene products p21 protein was analyzed with anti-N-ras p21 Meab by means of ABC method in 148 cases of skin and soft tissue neoplasmas. The results showed that 26 of 48 malignant melanomas(54.17%) and 4 of 13 congenital giant nevi (30.77%) were positive,all of 15 acquired nevi presented negative. There was a relationship between the expression of N-ras p21 and the depth of malignant melanoma invasion, pleomorphism and mitotic rate. The expression of N-ras p21 was low in other neoplasmas of skin and soft tissue. It was suggested that the genesis and prognosis of malignant melanoma might be related to the overexpression of N-ras p21 protein,but other neoplasmas of skin and soft tissue might not be connected with the activation of ras oncogene.
出处
《中国皮肤性病学杂志》
CAS
北大核心
1993年第4期207-208,267,共2页
The Chinese Journal of Dermatovenereology
基金
国家自然科学基金
关键词
软组织肿瘤
蛋白
基因
皮肤肿瘤
Neoplasmas,skin and soft tissue Nras p21 protein
