摘要
我们对153例因胃肠道症状接受胃镜检查的连续患儿进行前瞻性活检组织学、尿素酶试验及血清学检查,探讨幽门螺杆菌(HP)感染和上胃肠道疾病关系,并和成人及健康儿童对照。结果显示,消化性溃疡患儿HP感染率15/22(68％),明显高于功能性消化不良29/130(22％),而后者和健康儿童62/181(34％)无显著差异,提示HP和消化性溃疡相关,但与症状无关。儿童HP相关性胃炎内镜无特异性征象,组织学多集中在胃窦部,炎症细胞浸润和活动较明显。
We have performed a prospective study on 153 consecutive symptomatic children undergoing gastroscopy using methods of histology, serology, urease test for Helicobacter pylori (HP) infection. The data of symptomatic adults and healthy children were used as controls. Hp incidence in children with peptic ulcer (15/22,68％) was significantly higher than that of functional dyspepsia (29/130,22％), but did not differ from that of healthy children (62/181,34％). The results suggested that there was a link in HP infection and peptic ulcer disease and no correlation between HP infection and symptoms. No endoscopic characteristic was found in Hp associated gastritis. Histologically HP gastritis predominated the antrum and inflammatory cell infiltration and activity were obvious.
