摘要
胡黄连(Picrorhiza kurrooa Royle ex Benth.)为我国传统中药,一向依赖进口。本世纪70年代以来,在西藏和云南西北部发现西藏胡黄连(P.scrophulariiflora Pennell)并栽培作为印度产胡黄连的代用品。本文详细研究西藏胡黄连的化学成分,分离到3个已知的环烯醚萜甙,分别为amphicoside,catalpol和aucubin,一个已知的酚甙androsin;两个葫芦素类苦味甙,其中一个已知化合物鉴定为25—乙酰氧基-2β-葡萄糖氧基-3,16,20-三羟基-19-失羊毛甾烷-5,23-二烯-22-酮。另一个新化合物经光谱分析,化学结构证明为2β-葡萄糖氧基-3,16,20,22-四羟基-9-甲基-19-失羊毛甾烷-5,24-二烯。研究结果表明,西藏胡黄连与印度产的胡黄连化学成分十分相似,联系到二者在植物形态上的相似性和地理分布上的连续性,从化学的角度进一步证明这两种植物在系统演化上的密切关系,而且为国产西藏胡黄连作为进口印度胡黄连的代用品提供了依据。
From the roots of Picrorhiza scrophulariiflora Royle ex Benth.. a new bitter cucurbitacin glycoside was isolated together with three known indoidal glycosides, amphicoside (picroside-Ⅱ) (3), catalpol (4), aucubin (5), a phenol glycoside, androsin (6) and a known cucurbitacin glycoside (2). By means of spectroscopic evidence (UV, IR, FAB-MS, 1H, 13C NMR, DEPT, COSY), the structure of the new compound was elucidated as 2β-glucopyranosyloxy-3, 16, 20, 22-tetrahydroxy-9-methyl-19-norlanosta-5, 24-diene (1). The results show that the chemical constituents of P. scrophulariiflora are very similar to those of P. kurrooa. Further considering the resemblance in plant morphology and the continual distribution in geography, it could be concluded that the two species are very close in the phylogeny, and both can be used as the same traditional drug.
出处
《云南植物研究》
CSCD
1993年第1期83-88,共6页
Acta Botanica Yunnanica
关键词
西藏胡黄连
玄参科
化学成分
Picrorhiza scrophulariiflora', Scrophulariaceae
Cucurbitacin glycosid
Iridoidal glycosides
