摘要
目的 设计合成磷酸二酯酶抑制剂米力农, 鉴定结构。方法 运用乙酰化反应、缩合反应和环化反应合成米力农, 高效液相色谱法 (HPLC) 测定纯度, 通过元素分析和UV、IR、1H NMR、13C- NMR、MS鉴定结构。结果 制得了米力农, 纯度≥99. 50%, 确证了结构。结论 所用合成工艺合理可行, 条件温和, 操作简便, 收率优良。
Objective To design and synthesize phosphodiesterase inhibitor milrinone and identificate its structure.Methods The milrinone was synthesized by acety-lation,condensation and cyclic reaction.The purity was determited by HPLC and the structure was identificated by elemental analysis,UV,IR, 1H-NMR, 13C-NMR,and MS. Results The milrinone was obtained,purity≥99.50%,structure were confirmed.Conclusion The synthetic technology is feasible and the conditions were mild.The method is convenient with excellent yield.
出处
《华中科技大学学报（医学版）》
CAS
CSCD
北大核心
2005年第1期74-75,共2页
Acta Medicinae Universitatis Scientiae et Technologiae Huazhong
