摘要
目的 :探讨慢性肝病患者血清 HBV DNA含量与乙肝标志物 (HBVM)和肝损害程度的关系。方法 :分别用定量聚合酶链反应 (PCR)法和酶标法 (EL ISA)检测 2 0 7例乙型肝炎病毒慢性感染者血清 HBV DNA含量与乙肝病毒血清标记物(HBVM)。结果 :HBs Ag(+) ,HBe Ag(+) ,抗 - HBc(+)患者血清 HBV DNA含量 (10 7.4 0 70± 2 .3830 拷贝 / m l)显著高于 HBs Ag(+) ,抗 - HBe(+) ,抗 - HBc(+)患者的含量 (10 5.1 2 51± 3.4 797拷贝 / ml) (P <0 .0 0 1) ;不同临床类型 HBV感染者 HBV DNA含量 :慢性肝炎轻、中、重度 ,肝炎后肝硬化 ,慢性重症肝炎 5组间无显著性差异 (P >0 .0 5 )。结论 :HBV DNA含量与 HBe Ag密切相关 ;HBV
Objective:To investigate the relationship between HBV DNA quantity and HBVM,and the liver injury in patients with chronic hepatitis B virus infection Methods:HBV DNA quantity was detected by PCR and HBVM was detected by ELISA in 207 patients with chronic hepatitis B virus infection Result:The quantity of HBV DNA in patients with HBsAg,HBeAg and Anti HBc(10 7 407 0±2.383 0 copy/ml) positive was significantly higher than that in patients with HBsAg,Anti HBe and Anti HBc(10 5 125 1±3 479 7 copy/ml) positive (P<0 001);There was no statistic difference between chronic mild,middle and severe hepatitis B,liver cirrhotic and chronic fulminant hepatitis(P>0 05).Conclusion:These results suggest that a significant correlation between the quantity of HBV DNA and HBeAg;and the serum HBV DNA levels may have no relationship with hepatitic inflammatory activity in patients with chronic hepatitis B virus infection.
出处
《广西医科大学学报》
CAS
2003年第4期491-492,共2页
Journal of Guangxi Medical University
