摘要
用单克隆抗体OKT_3,OKT_4及OKT_8对40例原发性血小板减少性紫癜患者外周血T淋巴细胞及其亚群进行了分析,结果表明,该病患者T抑制/杀伤细胞亚群增高。
The T Lymphocyte and its subpopulations were dissected using three kinds of monoclonal antibodies OKT_3,OKT_4 and OKT_8 inperipheral blood of 40 patients,including adults and children withacute or chronic idiopathic thrombocytic purpura(ITP)。The resultsshowed that the total number of lymphocytes,T cells and T helper/indu-cer subset have no apparent changes,while T suppressor/cytotoxiccells increase remarkably,and in consequence the ratio of TH/TSdecrease in ITP cases.Studies also revealed that the changes of T cellsubsets have no apparent co-relations with sex,age or immunosuppressivetherapy,but correlate to PAIgG negatively;disturbance of T cell subsetsin chronic ITP is more prominent than that in acute form.Thesechanges are considered unlikely to have direct relationships with thepathogenesis of ITP,but rather represent a phenomenon or result ofdisease evolution.
出处
《山东医科大学学报》
1989年第2期66-69,共4页
Acta Academiae Medicinae Shandong
关键词
血小板减少
紫癜
T-淋巴细胞
Purpura,thrombopenic
T lymphocytes
Antibodies,monoclonal
Killer cells
