摘要
[目的]通过测定心肌梗死、不稳定心绞痛患者的血清肌钙蛋白I(CTNI)、肌酸激酶(CK)及其同工酶(CK-MB),探讨其对早期心肌损伤性疾病的诊断价值.[方法]CTNI的测定利用BeckmanAccess全自动免疫分析仪,采用免疫散射比浊法;CK-MB的测定利用日本OLYMPUSAU400全自动生化分析仪,采用酶法.测定56例急性心肌梗塞(AMI)患者、43例不稳定性心绞痛(UAP)患者和50例健康体检者血清肌钙蛋白I(CTNI)、CK、CK-MB;并作相关统计学分析.[结果]AMI组血清CTNI明显高于正常对照组(P<0.01),敏感度为92.98％,特异性为97.96％,UAP组血清CTNI亦明显高于正常对照组(P<0.01).[结论]肌钙蛋白I联合检测CK、CK-MB,在早期心肌损伤的诊断、疗效检测方面具有重要意义.
[Objective] To investigate the specific change of cardiac troponin I(CTNI) ,creatine kinase(CK) , creatine kinase-MB(CK-MB)in acute myocardial infraction (AMI) and unstable angina pectoris ( UAP) ,to provide an early diagnostic window and detection in the course of diseases. [Methods] Serum from 56 patients with coronary heart disease (AMI) ,43 patients with unstable anigina pectoris (UAP) and 50 healthy people was examined for CTNI,CK,and CK-MB, and respective comparison with each other was made. To start the test with Beckman Access auto immunosobant experment and OLYMPUS AU400 auto biochemical analysis experiment by immunitive chemical methods. [Results] The sensitivity and specificity of cardiac damage were 92. 98% and 97. 96% in AMI;72. 36 and 78. 06% in UAP,CK wee 48% and 44% ,CK-MB were 76% and 55. 5%. The positive rates of CTNI in AMI and UAP were significantly higher than those of CK-MB and CK. [ Conclusion ] The serum level of CTNI can closely reflect the extent of myoeardial damage in AMI, it provides an early diagnosric window for detection of AMI if examined with CK-MB and CK. Serum level of CTNT,CK and CK-MB are markers with high sensitivity and specificity for AMI and can aid in the early diagnosis of acute myocardial disease.
出处
《大连大学学报》
2004年第6期60-62,共3页
Journal of Dalian University
