摘要
本文应用Meta分析方法对国内多个有关乙型肝炎与肝癌关系的病例对照研究进行了定量综合分析。采用固定效应模型(Fixed effect model)和随机效应模型(Random effect modl)处理数据。HBsAg、HBV总感染、抗—HBs,抗—HBc的综合OR分别为11.61、11.19、0.21、7.84;它们的PAR分别为60.15％、85.99％、79％(预防分值)、70.61％。另对可能的混杂和偏倚进行了分析讨论。
In the present paper, case-control studies on the relationship between HBV infection and hepatocellular cancer in China were analyzed and evaluated by means of meta-analysis method. Fixed effect model and Random effect model were applied to process data. The pooled OR (Positive v.s. negative) of HBsAg, HBV overall infection, anti-HBs, anti-HBc were 11.61, 11.19, 0.21, 7.84 respectively and their PAR were 60.15%, 85.99%, 79% (preventive fraction), 70.61% respectively. The possible bias and confounding were also discussed.
出处
《现代预防医学》
CAS
1993年第4期193-197,共5页
Modern Preventive Medicine
关键词
META分析
肝肿瘤
乙型肝炎
Meta-analysis
Hepatocellular
Cancer
HBV
Case-con-trol studies
