摘要
为了探讨金属螯合剂 EDTA 对多肽药物胰岛素经眼吸收给药的作用,用36只纯种新西兰大耳白家兔以经眼给药的方式对 EDTA 与国产胰岛素进行了研究,结果表明:①加 EDTA 与不加 EDTA 的胰岛素溶液经眼给药后其血中药物峰值浓度前者要比后者高3—4倍,并使生物利用度提高4—6倍,药物浓度一时间下曲线面积(AUC)和血药浓度均大于不加 EDTA 组。②降血糖的效果加 EDTA 的比不加 EDTA 的胰岛素溶液提高3—4倍。故而初步认为金属螯合剂 EDTA 对胰岛素经眼吸收有促进作用。
In order to evaluate the effect of EDTA on the systemic absorption of polypeptide
insulin through the eyes,36 New Zealand Rabbits were used to study.The results showed
that:①the insulin concentrations in the blood for insulin solution with EDTA were more
3—4 folds than that for without EDTA,bioavailibility more 4—6 folds、area under blood con(?)-
entration-time curve(AUC)and maximiun as well;②the effects of reduction blood sugar
levels of insulin solution with EDTA were more 3—4 folds than without EDTA.It is suggested
that EDTA has a enhance effect for insulin absorption through the eyes.
