摘要
Statins, 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors are widely used for the treatment of hypercholesteremia and have showed remarkable activity in preventing cardiovascular morbidity and mortality. Recent studies demonstrated that statins have significant antithrombotic effect in addition to cholesterollowering action. Although the efficacy of statins for reducing cardiovascular events has historically been ascribed to their inhibitory activity on cholesterol synthesis, the degree of low-density lipoprotein cholesterol reduction by statins generally does not correlate with the magnitude of coronary risk reduction.
出处
《血栓与止血学》
2005年第1期3-4,共2页
Chinese Journal of Thrombosis and Hemostasis
关键词
抗血栓形成
还原酶抑制剂
预防
治疗
HMG-GoA reductase inhibitor
Statins
Antithrombotic effect
