摘要
目的 确定在环磷酰胺 (CTX)化疗过程中静点碳酸氢钠的时间 ,有效地减轻环磷酰胺对肾脏的毒性作用。方法 将 72例采用含CTX联合化疗的病人分为 2组 ,分别于化疗前和化疗后输入碳酸氢钠 ,观察 2组病人的肾功能、血尿酸、尿pH值和出血性膀胱炎的相关症状。结果 化疗后输入碳酸氢钠碱化尿液效果明显优于化疗前输入碳酸氢钠。结论 在环磷酰胺化疗中应将碳酸氢钠的输入时间安排在输入环磷酰胺以后更为稳妥。
Objective To ensure optimum sequence of intravenous transfusion baking soda during chemotheraphy of cyclophosphane treatment,and in order to relieve cyclophosphane side effect to kidney. Methods 72 patients who were treated with cyclophosphane combined with other drugs were classified two groups. A group were preceded BS with cyclophosphane, B group were treated with BS and cyclophosphane in reverse order. We examined their kidney function, uric acid in the blood, uric pH. Results The effect SB should be precede CTX during cyclophosphane treatment. Conclusion It is reliable to arrange transfusion of BS before injecting cyclophosphane during cyclophosphane chemotheraphy.
