摘要
背景:绝经期妇女雌激素水平下降后出现骨吸收增强,同时伴有细胞因子增多,骨代谢紊乱。进一步观察骨质疏松患者血清中白细胞介素6(IL-6)、骨钙素、尿胶原吡啶酚(pyridinoline,PYD)、雌二醇的水平,有利于判定上述因子是否与骨质疏松发生发展有关。目的:探讨女性骨质疏松患者的血清中IL-6,骨钙素与雌二醇,尿液中PYD的水平与骨代谢的关系,寻找骨质疏松症发生发展的可能有关因素。设计:以患者和健康体检者为研究对象,病例-对照,观察对比研究。单位:深圳市南山人民医院骨科中心实验室。对象:选择1999-01/2001-12深圳市南山人民医院骨科收治的25例绝经期女性骨质疏松患者为实验组,年龄42～69岁。选择同期本院健康体检女性10例为对照组。方法:空腹抽取实验组和对照组研究对象静脉血2mL,分离血清,同时收集晨尿2mL,分别测IL-6,骨钙素,PYD和雌二醇的含量。主要观察指标:两组血清IL-6,骨钙素,雌二醇水平及尿液中PYD比较。结果:实验组的25例患者IL-6犤(201.0±79.9)ng/L犦,骨钙素犤(25.5±16.2)μg/L犦,PYD犤(41.3±9.7)nmol/mmol肌酐犦均明显高于对照组(t=2.159～2.953,P<0.05～0.01);实验组血清雌二醇水平犤(79.8±73.2)ng/L犦明显低于对照组(t=2.071,P<0.05)。结论:IL-6,骨钙素,PYD,雌二醇在骨质疏松的发生、发展?
BACKGROUND:In post-menopausal women,the reduction of estrogen level is followed by gradual increase of bone absorption,accompanied by increased cytokine synthesis and bone metabolism disorder.Observation of serum interleukin-6(IL-6),osteocalcin(OC), estradiol(E2) and urinary pyridinoline(PYD) in women with osteoporosis may help understand role of these factors in the onset and development of osteoporosis. OBJECTIVE:To investigate the relationship of serum IL-6,OC,E2, and urinary PYD levels with bone metabolism in women with osteoporosis,so as to identify the factors responsible for the occurrence and development of osteoporosis. DESIGN:A case-controlled clinical observation. SETTING:Central Laboratory of Orthopedics,Nanshan People's Hospital of Shenzhen City. PARTICIPANTS:Between January 1999 and December 2001,25 post-menopausal women with osteoporosis aged 42-69 years were selected from the Department of Orthopedics,Nanshan People's Hospital of Shenzhen to constitute the experimental group,with 10 healthy women from the same hospital serving as control group. METHODS:Two milliliters of fasting venous blood and 2 mL urine samples were collected from women in both groups in the morning to determine the contents of IL-6,OC,PYD and E2,respectively. MAIN OUTCOME MEASURES:Serum IL-6,OC,E2 and urinary PYD levels in the subjects. RESULTS:In the experimental group,the IL-6 level was(201.0 ±79.9) ng/L,OC(25.5±16.2) μg/L,and PYD(41.3±9.7) nmol/mmol(creatinine),all significantly higher than those in control group(t=2.159-2.953,P< 0.05-0.01).Serum E2 level in the experimental group(79.8±73.2) ng/L,however,was significantly lower than that in control group(t=2.071,P< 0.05). CONCLUSION:IL-6,OC,PYD and E2 may play important roles in the occurrence and development of osteoporosis,and adjustment of the levels of these factors can be necessary in the treatment of women with osteoporosis.
出处
《中国临床康复》
CSCD
北大核心
2005年第7期222-223,共2页
Chinese Journal of Clinical Rehabilitation
