摘要
背景:目前针对早期糖尿病自主神经病变(diabeticautonomicneuropa-thy,DAN)的诊断和检测方法的研究十分薄弱。目的:利用非线性心率变异性(HeartRateVariability,HRV)方法帮助了解自主神经受损的程度,从而为糖尿病自主神经病变的早期诊断提供临床依据。设计:单一样本研究。单位:一所大学分校的计算机教研室和一所大学生物医学工程系的医学物理教研室。对象:本实验于2003-03/05在解放军第一军医大学生物医学工程系医学物理教研室。实验纳入的糖尿病患者34例为解放军第一军医大学附属南方医院内分泌科住院患者;伴有DAN者22例。正常人40例为解放军第一军医大学师生和解放军体育学院体育系学生。采样点数(去除异常值后)为512个。方法:采用自行研制的基于虚拟仪器开发平台LabVIEW的HRV采集分析系统,分别采集了74组(74组信号来源于34例糖尿病和40例正常人)标准相邻R波的间期(RwavetoRwaveintervals,RRI)信号。用非线性预测方法对糖尿病患者与正常人的RRI信号进行分析。主要观察指标:74组标准相邻R波的间期信号的采集与分析结果。结果:采用NMSE分析时,无DAN病变的患者与正常人比较,差异无显著性意义(P=0.075),而发生DAN的患者与正常人比较,差异有显著性意义(P=0.001);采用MAE分析时。
BACKGROUND:Researches on the diagnosis and detection methods of diabetic autonomic neuropathy(DAN) is very weak at present. OBJECTIVE:To get the data about the degree of autonomic neuropathy by using the nonlinear heart rate variability(HRV) so as to provide clinical evidence for the early diagnosis of DAN. DESIGN: A single sample study. SETTINGS:Computer department in a university; Staff room of medical physics of department of biomedical engineering in a university. PARTICIPANTS:The experiment was completed in the Staff Room of Medical Physics,Department of Biomedical Engineering in the First Military Medical University of Chinese PLA from March to May 2002.Thirty-four diabetic patients,including 22 with DAN complications,were selected from the inpatients of Department of Endocrinology in the Affiliated Nanfang Hospital of the First Military Medical University of PLA,and other 40 normal subjects,who were from the faculty in the First Military Medical University of Chinese PLA and students in the Department of Physical Education,Chinese PLA Institute of Physical Education,were taken as the controls.The R wave to R wave intervals(RRI) time series is sampled and corrected to 512 points for analysis. INTERVENTIONS:Based on the virtual instrumental workbench-LabVIEW,74 standard adjacent RRI signals were selected from 34 diabetic patients and 40 normal cases,and then analyzed with the method of nonlinear predictability. MAIN OUTCOME MEASURES:Collective and analytical results of the 74 standard adjacent RRI signals. RESULTS:There was no significant difference between the diabetic patients without DAN and the controls by the analysis with normalized mean square error(NMSE) NMSE(P=0.075),but the significant difference between the DAN patients and the controls(P=0.001).While significant analysis between the diabetic patients without DAN complications and the controls was significant by the analysis of mean absolute error(MAE)(P=0.007 and P=0.000), there was also significant difference between the diabetic pati
出处
《中国临床康复》
CSCD
北大核心
2005年第7期190-192,共3页
Chinese Journal of Clinical Rehabilitation
基金
广东省重点科技攻关项目(99M04701G)~~
