摘要
目的探讨神经元特异性烯醇化酶(NSE)在判断急性颅脑损伤患者脑损伤程度和预后方面的价值以及尼膜同在颅脑损伤治疗中的作用。方法将44例急性颅脑损伤患者分为常规治疗组和尼膜同组,另取13例作为正常对照。用双抗体夹心酶标免疫分析法分别测定患者入院即时、第3天及第7天血清NSE,结果进行统计学处理。结果所有患者入院即时血清NSE(38.75±8.89)ng/mL均较正常对照(10.57±3.20)ng/mL明显增高(P<0.001),且与GCS评分呈负相关(r=-0.678,P<0.01);不同类型颅脑损伤患者之间血清NSE存在组间总变异(F=15.185,P<0.01);伤后第7天,尼膜同组血清NSE(21.70±7.03)ng/mL明显低于常规治疗组(27.10±7.73)ng/mL,差异有显著性(P<0.05)。结论血清NSE水平与颅脑损伤的程度有关,动态监测血清NSE有助于观察脑外伤患者病情变化、估计预后;尼膜同可能有助于降低血清NSE,促进颅脑损伤的恢复。
To study the effect of Neuron-specific enolase (NSE) on deciding the levels of brain injury and the prognostic value in patients with acute head injury as well as the protective effect of Nimotop on cerebral injury. The 44 patients was divided into the routine therapy group and Nimotop group. The serum NSE was examined within 24 h, on the 3th day and the 7th day of the patients by method of Sandwich ELISA repectively. The results were analysed statistically. The serum NSE of all patients within 24hs (38.75±8.89) ng/mL were much higher than that of normal control (10.57±3.20) ng/mL and was negatively correlated with the GCS (r =-0.678, P <0.01). The significant differences were found between groups of different kinds of head injury. On the 7th day, the NSE of Nimotop group (21.70±7.03) ng/mL was significantly lower than that of routine group (27.10±7.73) ng/mL. [Conclusion] The serum NSE is correlated with the levels of head injury. Monitoring the NSE continuously can estimate the conditions of patients, suggesting its prognosis. Nimotop can lower the serum NSE by decreasing the secondary cerebral injury.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2005年第3期424-426,429,共4页
China Journal of Modern Medicine
