摘要
目的 探讨慢性进行性眼外肌麻痹 (CPEO)的临床病理特征。方法 应用光镜、电镜和酶组织化学对 2例CPEO肌肉活检标本进行形态学观察。结果 HE染色肌组织中见散在分布的 ,多少不等的嗜盐基性肌纤维。在改良GOMORI三色染色上 ,这些嗜盐基性肌纤维边缘由于呈现不规则红色 ,即称不整边红纤维或破碎红纤维。细胞色素氧化酶 (CCO)和琥珀酸脱氢酶 (SDH)双染色 ,阳性的蓝色纤维与不整边红纤维的分布一致 ,数量也较改良GOMORI三色染色增多。结论 改良GO MORI三色染色应作为诊断线粒体疾病的常规染色 。
Purpose To investigate the clinical pathologic features of chronic progressive external ophthalmoplegia (CPEO). Methods Two muscle biopsies cases of CPEO were examined by light microscopy, electron microscopy and enzyme histochemistry. Results Routine stains showed scattered dark ‘ragged red fibers’ (RRF). These fibers showed a ragged-red on modified gomori trichrome, and markedly increase in oxidative enzyme activity by double stains of cytochrome-c oxidoreductase (CCO) and succinate dehydrogenase (SDH)). Conclusions Modified Gomori trichrome stains should be a routine stain. Double stains of CCO/SDH may be valuable for making diagnosis of mitochondrial diseases.
出处
《临床与实验病理学杂志》
CAS
CSCD
2004年第6期692-694,共3页
Chinese Journal of Clinical and Experimental Pathology
