摘要
【目的】观察纳洛酮对创伤性脑损伤 (TBI)患者血浆内皮素 (ET)、降钙素基因相关肽 (CGRP)、神经组织蛋白 (S 10 0B)含量的影响 ,探讨纳洛酮对急性TBI患者的治疗效果。【方法】用放射免疫测定法测定TBI患者血浆ET 1、CGRP的含量变化 ,用酶联免疫吸附实验测定S 10 0B的含量变化。【结果】①脑损伤后患者血浆ET 1(d1、d3 、d5)明显升高 ,病情越重升高越明显 ;②纳洛酮治疗后血浆ET 1含量下降较对照组显著 ,CGRP早期 (d1)较对照组明显升高 ;③TBI患者血浆中脑损伤特异性蛋白S 10 0B明显升高 ,脑损伤程度越重 ,升高越明显。【结论】①TBI患者血浆ET 1及S 10 0B水平升高 ,与病情严重程度有关。②ET、CGRP平衡失调在TBI的病理过程中起到重要作用。③早期应用纳洛酮可以显著降低ET 1及S 10 0B血浆含量 ,提高CGRP水平 。
ObjectiveTo observe the effects of naloxone on the plasma levels of endothelin-1 (ET-1),calcitonin gene related peptide(CGRP) and S-100 B (a kind of nervous tissue protein) in patients with traumatic brain injury(TBI) and investigate its therapeutic efficacy for patients with acute TBI.The plasma level changes of ET-1 and CGRP in patients with TBI were estimated by radioimmunoassay (RIA) and those of S-100B was detected by ELSIA.①The plasma levels of ET-1 and S-100B increased significantly at 1st,3rd and 5th day after TBI ; the more was the severity of injury, the more prominent was the elevation. ②The plasma levels of ET-1 decreased more markedly after the therapy of naloxone than those of controls,but the increase of plasma CGRP levels was more obvious than the controls in the early period (1st day). ③The plasma levels of S-100B in patient with TBI distinctly increased, the degree of increase was dependent on the severity of brain injury.[Conclusions]①The increase of plasma ET-1 and S-100B levels is related with the severity of trauma. ②Imbalance of ET-1 and CGRP plays an important role in the pathological process of TBI. .③Early application of naloxone can remarkably decrease the plasma levels of ET-1 and S-100B, elevate the plasma levels of CGRP and get satisfactory therapeutic efficacy in patients with TBI.
出处
《医学临床研究》
CAS
2004年第11期1256-1259,共4页
Journal of Clinical Research
