摘要
目的 探讨检测血清抗结核脂阿拉伯甘露糖 B和 38kd抗体 IgG (LAM B+38kd IgG)对儿童结核病的诊断价值。方法 检测采自235例患儿的标本(包括血清、脑脊液、胸水、腹水、胃液)中抗结核抗体。结果 血清抗体阳性率:(1)肺内、外结核组两组间无显著性差异(P>0.05),分别为32.14%(18/56) 和20.41%(10/49);(2)菌检阳性组明显高于菌检阴性组抗体阳性率分别为64.00%(16/25)和34.29%(12/35),组间有显著性差异(P<0.05)。结论 血清抗LAM B+38kd IgG检测对结核病儿童有辅助诊断价值。
Objective To evaluate the diagnostic value of antimycobacterial tuberculosis antibodies-lipoarabinomannan-B and 38kd-IgG(LAM-B+38kd-IgG)in children with tuberculosis.Methods LAM-B+38kd-IgG in 207 sera specimens,43 cerebrospinal fluid,8 pleural fluid,5 ascitic fluid,4 gastric juice specimens obtained from 235 children with tuberculosis and non-tuberculosis were detected by the dot immunogold filtraton assay(DIGFA).Rrsults The positive rate of LAM-B38kd-IgG in sera was 26.67%(28/105) in tuberculosis group and the false-positive rate of LAM-B38kd-IgG in sera was 1.96%(2/102) in non-tuberculosis group.The positive rate of LAM-B+38kd-IgG in sera in pulomnary tuberculosis group and extrapulmonary tuberculosis was 32.14%(18/56) and 20.41%(10/49),respectively,and there was nonsignificant difference between two groups(P>0.05).The positive rate of the antibodies(in sera)in combined-group of bacteriology examination. M.tuberculosis positive resultes was obviously higher than that of those in negative resultes group(64.00% vs 34.29%).There was significant difference between two groups(χ 2=5.1735,P<0.05).Conchusion The results suggested that the detection of LAM-B+38kd-IgG in sera was a useful supplementary tool for diagnosis of tuberculosis in children.
出处
《重庆医学》
CAS
CSCD
2005年第2期206-207,共2页
Chongqing medicine
