摘要
背景:骨髓基质细胞具有强大的增殖能力和多向分化潜能,将骨髓基质细胞作为神经元的另一来源用于中枢神经系统疾病或损伤的治疗,已越来越受重视。目的:回顾骨髓基质细胞在中枢神经系统疾病修复中的研究和进展。资料来源:应用计算机检索medline1995-01/2004-01与骨髓基质细胞的应用的相关文章,检索词为“bonemarrowstromalcell,centerner-voussystem,并限定文章语言种类为English。同时计算机检索中国期刊网专题全文数据库2002/2004的与骨髓基质细胞相关文章,限定文章语言种类为中文,检索词为“骨髓基质细胞、中枢神经系统”。资料选择:对资料进行初审,选取有对照组的文章,排除明显不随机的文献,综述和Meta分析同时被排除,同一领域的选择近期发表或发表在权威的杂志的文章。对剩余的文献开始查找全文。资料提炼:共收集到12篇符合纳入标准文章。资料综合:12篇文章包含了骨髓基质细胞多潜能性、骨髓基质细胞的分离、骨髓基质细胞的分化和诱导、骨髓基质细胞的鉴定以及骨髓基质细胞移植治疗中枢神经系统疾病的研究现状等方面的进展。结论:骨髓基质细胞应用于中枢系统疾病修复的前景看好。
BACKGROUND:The stroma cell of bone marrow has strong ability in proliferation and differentiation.The method that the application of stroma cell of bone marrow considered as neuronal another source is used to treat on central nervous system(CNS) disease or damage has been thought highly day by day. OBJECTIVE:To review the research and progress of bone marrow stromal cell(BMSC) in plerosis of central nervous system disease. DATA SOURCES:Using the key terms bone marrow stromal cell,center nervous system,we searched the MEDLINE database of all articles on application of BMSC in English published between January 1995 and January 2004.Meantime,using the same key terms in Chinese, we searched Chinese journals full text database between 2002 and 2004. STUDY SELECTION:All articles were selected firstly,the articles containing the control group were collected,and the non randomized trials,review and Meta analysis were excluded.The articles published in authoritative journals or published recently in the same field were collected and the rest full text was looked up. DATA EXTRACTION:A total of 12 articles which met inclusion criteria were collected. DATA SYNTHESIS:Twelve articles almost involved every direction of the research of BMSC,such as the multipotency,isolation,differentiation,induction,evaluation of bone marrow stroma cell and the present situation of the research of bone marrow stromal cell in plerosis of central nervous system disease,etc. CONCLUSION:The future of the application of BMSC in plerosis of CNS disease is brilliant.
出处
《中国临床康复》
CSCD
北大核心
2005年第5期148-149,共2页
Chinese Journal of Clinical Rehabilitation
