摘要
目的 应用灰阶超声造影定量研究肝恶性肿瘤对其周围肝实质血流动力学的影响及其诊断价值。方法 分别经耳缘静脉对8只新西兰大白兔荷VX2 瘤前、后团注超声造影剂SonoVueTM(0.1 ml/kg),应用CnTi(contrast tuned imaging) 低机械指数实时灰阶造影调谐成像技术和声学定量时间强度曲线分析软件,定量分析兔荷瘤前、后肝实质造影增强效应。结果 在造影过程中,肿瘤及肝实质内造影剂随时间呈动态增强,其时间-信号强度曲线客观反映造影剂显影的全过程。与荷瘤前相比,荷瘤后肝实质造影剂开始增强时间和达到峰值时间均较早,峰值强度较强,显影时间短,但其变化轻微。荷瘤前、后肝实质各造影定量参数间差异均无显著性意义(P>0.05)。结论 灰阶超声造影不能完全反映肝恶性肿瘤对其周围肝实质血流动力学影响;肝实质超声造影定量分析对肝恶性肿瘤的诊断及预示价值尚待进一步研究。
Objective To study the hemodynamic changes of peri-neoplastic liver parenchyma with gray-scale contrast enhancement.Methods Ultrasound contrast agent SonoVue TM( 0.1 ml/kg) was applied respectively in 8 rabbits by intravenous bolus injection before and after VX 2-bearing.Corresponding parameters of the time-intensity curve: time to enhancement (ET),time to peak intensity (PIT),peak signal intensity (PSI) and mean transit time (MTT) were measured using low mechanical index contrast gray-scale imaging and Wash-in/Wash-out time intensity curve software.Results Contrast enhancement in VX 2 tumor and liver parenchyma,from starting to enhancement,getting to peak signal intensity,to decreasing with time,was observed in all the rabbits. The ET and PIT were slightly earlier,the PSI higher and the MTT shorter in liver parenchyma of VX 2-bearing than those of none VX 2-bearing.However,there was no significant difference of parameters of the time-intensity curve of liver parenchyma between before and after VX 2-bearing of the rabbits (P> 0.05).Conclusions Gray-scale contrast enhancement does not fully evaluate the hemodynamic changes of peri-neoplastic liver parenchyma.It needs further study to relate quantitative parameters of peri-neoplastic liver parenchyma to malignant tumor diagnosis.
出处
《中华超声影像学杂志》
CSCD
2005年第2期144-146,共3页
Chinese Journal of Ultrasonography
