摘要
目的了解我院医院感染致病菌肠球菌耐药谱的变化,指导临床合理用药。方法应用回顾性调查分析方法对我院自2000年1月～2003年12月临床标本中分离的主要病原菌的药敏试验进行统计分析。结果病原菌仍以革兰阴性杆菌为主,占50.5%,但革兰阳性球菌占39.7%,且有逐年上升趋势;检出的517株肠球菌中,粪肠球菌有400株,占77.40%,屎肠球菌有117株,占22.69%;除万古霉素外,呋喃妥因、替考拉宁、氨苄西林/舒巴坦对粪肠球菌保持较高的敏感性,万古霉素、呋喃妥因、替考拉宁对屎肠球菌也有较高的抗菌活性;四环素、氯霉素对屎肠球菌的耐药率4年间呈下降趋势。结论屎肠球菌耐药性高于粪肠球菌,临床细菌耐药性日趋严重,应在医院开展细菌耐药性监测;指导临床合理应用抗菌药物。
OBJECTIVE To study the change in antibiotic resistance spectrum of some main enterococci. METHODS The antibiotic resistance of pathogens isolated from clinical samples in our hospital during Jan 2000 to Dec 2003 was studied retrospectively. RESULTS The Gram-negative bacilli were predominate (50.5%). ~Among 517 strains of enterococci, there were 400 strains of Enterococcus faecalis (77.40%) and 117 strains of E. faecium (22.69%). E. faecalis was much more sensitive to norvancomycin, nitrofurantoin, teicoplanin and ~ampicillin/sulbactam, E. faecium was much more sensitive to norvancomycin, nitrofurantoin and teicoplanin; the ~resistance rates of E. faecium to chloramphenicol and tetracycline have changed obviously (P<0.05). ~CONCLUSIONS The resistance rate of E. faecium is higher than that of E. faecalis. It is suggested that there be an urgent need for surveillance of bacterial resistance in different hospitals and rational use of antimicrobial ~agents be emphasized during clinical therapy.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2005年第1期115-117,共3页
Chinese Journal of Nosocomiology
基金
广东省医学科学技术研究基金资助项目(A2004290)
关键词
医院感染
肠球菌属
耐药性
Nosocomial infection
Enterococcus
Antibiotic resistance
