摘要
目的 探讨在常规放疗后立体定向放射治疗加量照射对鼻咽癌初治患者局部控制率和生存率的影响及并发症。方法 1998年 5月至 2 0 0 2年 12月 ,3 2例鼻咽癌初治患者 ,年龄 18~ 70岁 ,中位年龄 44岁。男性 2 5例 ,女性 7例。病理诊断均为鳞癌 ,临床分期为Ⅰ期 2例、Ⅱ期 16例、Ⅲ期 8例、Ⅳ期 6例。在常规外照射鼻咽部中位剂量 66Gy(64~ 72Gy)后给予立体定向放疗加量照射 ,中位剂量 12Gy(8~ 2 0Gy)。结果 本组患者 1、2、3年的鼻咽局部控制率分别达到96 3 %、89 0 %和 85 0 % ,1、2、3年的无瘤生存率分别为 92 6%、77 3 %和 66 0 %。除 1例患者在治疗后死于鼻咽大出血外 ,无其他特殊并发症发生。结论 鼻咽癌初治患者在常规外照射后给予立体定向加量照射 ,能够取得较好的局部控制率和生存率。
Objective To study the effects of stereotactic radiotherapy boost on the improvement of local control and survival of nasopharyngeal carcinoma. Methods Thirty-two consecutive patients were treated with stereotactic radiotherapy after radiotherapy for nasopharyngeal carcinoma from May 1998 to December 2002. All patients had biopsy confirmation of disease prior to radiation therapy: Stage Ⅰ disease (1 patient), Stage Ⅱ disease (16 patients), Stage Ⅲdisease (8 patients), and Stage Ⅳ disease (6 patients). Stereotactic radiotherapy was delivered with a frame-based LINAC as a boost (range: 8 to 20 Gy, median: 12 Gy) following fractionated radiation therapy (range: 64 to 72 Gy, median: 66 Gy). Results Four patients developed local recurrences, 3 cervical node recurrences, and 6 distant metastases at a mean follow-up of 33 months (range: 6 to 51 months). The local control rate in 1, 2, and 3 years after treatment for primary site were 96.3%, 89.0%, and 85.0% respectively. The disease free survival rate in 1, 2, and 3 years were 92.6%, 77.3% and 66.0%, respectively. There were no complications of treatment caused by stereotactic radiotherapy except for 1 patient who died from nasopharyngeal hemorrhage. Conclusion Stereotactic radiotherapy boost following fractionated EBRT can result in excellent local control and longer disease-free survival.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2004年第24期2203-2205,共3页
Journal of Third Military Medical University
关键词
鼻咽癌
立体定向
放射治疗
nasopharyngeal carcinoma
stereotactic
radiotherapy