摘要
目的:通过比较1型糖尿病牙周炎患者与无系统性疾病的牙周炎患者龈沟液β2微球蛋白(beta2-microglobulin,β2-MG)水平的差异,探讨β2-MG水平与1型糖尿病患者康复状况的关系。方法:2002-12/2003-12复旦大学附属华山医院门诊收治1型糖尿病牙周炎患者60例,选取35例,为1型糖尿病牙周炎组,男17例,女18例,年龄40～75岁,病程1～3年;同期复旦大学附属眼耳鼻喉科医院牙周科收治牙周病患者35例,为对照组,男17例,女18例,年龄35～73岁,病程2～3年。纳入标准:①诊断标准:1型糖尿病牙周炎组符合1985年WHO标准诊断,并至少1年以上;对照组符合Page等所述标准。②未经过牙周病治疗。③口内无修复体。④附着丧失所累及的牙数≥20颗。⑤所选牙的牙周探诊深度4～8mm。⑥X射线片显示牙槽骨吸收。排除标准:半年内服用过抗生素,过去3个月内服用非类固醇类抗炎药,有其他系统性疾病。用放射免疫方法测定1型糖尿病型牙周炎患者与无系统性疾病的牙周炎患者的龈沟液β2-MG水平。结果:35例1型糖尿病牙周炎患者龈沟液β2-MG含量为(0.987±0.936)mg/L,35例对照组牙周炎患者龈沟液β2-MG含量为(2.276±0.928)mg/L,两组比较差异有非常显著性意义(P<0.01),与牙周炎的严重程度成反比。直线相关分析结果表明:龈沟液β2-MG含量与空腹血糖含量呈?
AIM:To probe into the relationship between beta 2-microglobulin(β2-MG) level and the rehabilitation condition of patients with type 1 diabetes mellitus by comparing the difference in β2-MG level in gingival crevicular fluid(GCF) between the patients with type 1 diabetic periodontitis and the patients with systemically healthy periodontitis. METHODS:Thirty-five outpatients were chosen as the type 1 diabetic periodontitis group from 60 patients suffers from type 1 diabetic periodontitis in the Affiliated Huashan Hospital of Fudan University from December 2002 to December 2003,17 males,18 females,and 40-75 years old,1-3 courses of disease.At the same term,35 patients with periodontitis were chose as the contrast group from the Affiliated Ophthalmology and Otolaryngology Hospital of Fudan University,17 males,18 females,35-73 years old,2-3 courses of disease.The including criteria:①Diagnostic criteria:The type 1 diabetic periodontitis group accorded with diagnostic criteria of WHO in 1985 and the course of disease was more than one year;the control group accorded with diagnostic criteria of Page,etc.②Without periodontitis curing.③Without restoration in internal oral cavity.④The number of the teeth involved in loss of attachment was no more than 20.⑤The periodontal exploring depth of choosing teeth is 4 to 8 mm.⑥X-ray showed that the alveolar bone was absorbed.Excluding criteria:Antibiotics was used within half a year,the nonsteroid antibiotics was used during the past 3 months,and with systematical disease.The β2-MG levels in GCF of patients with type 1 diabetic periodontitis and patients with systemically healthy periodontitis were measured by radioimmunoassay. RESULTS:The β2-MG level in 35 patients with type 1 diabetic periodontitis was(0.987±0.936) mg/L.The β2-MG level in 35 patients in the control group was(2.276±0.928) mg/L.There was a significant difference between the two groups(P< 0.01),and there was an inverse ratio between the β2-MG level and severity degree of periodontitis.The linear
出处
《中国临床康复》
CSCD
北大核心
2005年第3期128-129,共2页
Chinese Journal of Clinical Rehabilitation
