摘要
目的：探讨原发性肝癌与人类白细胞抗原（HLA）Ⅰ类基因系统多态性之间的关系。方法：采用微量淋巴细胞毒（MIC）方法，对31例诊断明确的原发性肝癌（PLC）患者和101例无血缘关系的健康汉族人进行研究。结果：PDC组HLA-B8抗原频率较对照组显著增加（RR＝30．15，P＜0．001）。结论：HLA-B8为PLC的易感基因，其可能与PLC致病基因连锁不平衡或直接作为免疫应答基因而导致PLC的发生。
Aim:To discuss the relation between PLC and HLA Ⅰ ttpe gene system. Method:31 cases diagnosed PLC pa-tients and 101 healthy Hans were taken examination with MLC method. Result:The antigen frequency of HLA - B8 in PLCgroup was significant higher than control group P < 0.001. Conclusion: HLA - B8 may be PLC susceptible gene,it may con-nect with PLC Pathogenic gene imbalance or cause PLC directly as an immune ask- answer gene.
出处
《黑龙江医学》
1999年第7期19-20,共2页
Heilongjiang Medical Journal
