摘要
目的评价国产聚丙烯酸（ＰＡＡ）凝胶治疗干眼症的临床疗效。方法在国内首次制备聚丙烯酸凝胶，并与美国产人工泪１．４％聚乙烯醇（ＰＶＡ）滴眼液治疗干眼症患者（各７０例）的疗效进行比较性观察。结果两种人工泪均能显著改善干眼症患者的主觉症状及客观体征（Ｐ＜０．０１），并且两者疗效各项指标比较无显著性差异（Ｐ＞０．０５），但角膜前停留时间ＰＡＡ明显长于ＰＶＡ（Ｐ＜０．０１）。结论国产聚丙烯酸凝胶人工泪治疗干眼症确实安全有效。
Objective To evaluate the therapeutic efficacy of the domestic polyacrylic acid(PAA) gel for the treatment of dry eyes. Methods 140 patients with dry eyes were randomly allocated to treatment with either PAA(70) or PVA(70) in a multicenter, prospective and open study. The parameters assessed included the foreign body sensation, dry eye sensation, hot sensation, pain, vision acuity, schirmmer's test (SIT), break-up time (BUT), rose bengal staining (RB ), the precorneal resident time after the first treatment and toxic or side effects. Results The two groups were similar in study parameters at baseline. Two kinds of artificial tears both significantly improved the patient's subjective symptoms and objective signs (P < 0. 01 ). The therapeutic efficacy of the treated and controlled group reached 84. 06% and 85. 51%, respectively(P > 0. 05 ), in spite of the fact that the precorneal resident time of PAA was much more than PVA(P < 0. 01 ). Conclusion Domestic PAA gel is safe and effective for the treatment of dry eyes.
出处
《眼科研究》
CAS
CSCD
北大核心
2001年第3期250-252,共3页
Chinese Ophthalmic Research
关键词
干眼症
人工泪
聚丙烯酸凝胶
dry eyes polyacrylic acid artificial tears
