摘要
目的 观察艾司洛尔对缓解气管拔管时期心血管反应的效果及安全性。方法 观察不同剂量艾司洛尔对全麻苏醒,气管拔管病人不同时间段的变化。结果 应用艾司洛尔2mg/kg组血压与心率恢复最快,与其他各组比较有显著性差。拔管后瞬间三组心率（HR）均增快,血压（MAP）皆升高,D组持续了5分钟;E1组持续了3分钟后恢复至基础水平;E2组拔管后瞬间MAP和HR均增加,但持续1分钟后MAP和HR皆恢复。结论 艾司洛尔可有效缓解气管拔管时期的心血管反应,且药效与剂量相关。
Objective To study of the preventionsl effect of esmolol on cardiovascular stress induced by tracheal extubation. Methods 60 ASA Ⅰ-Ⅱ patients undergoing nonheart surgeries were randomly and equally divided to receive saline, esmolol 1 micrograms/kg or 2 micrograms/kg infusions given as a bolus 2 min before extubation. HR, MBP data were taken and receded before and after dosing and 1,3, 5,10minutes after extubation. Results MBP and heart rate (HR) increased in all 3 groups during emergence and peaked at extubation. But the time required to recover these parameters to the pre-extubation level differs in groups. In this respect, the 2 mg/kg esmolol group was obviously superior to that of other groups. It only required 1 minute for MAP and HR in 2 mg/kg group and 3 minutes in 1 mg/kg group and 5 minutes in control group. Conclusion Esmolol is effective in preventing cardiovascular reaction induced by extubation which is dose related.
出处
《浙江创伤外科》
2001年第6期357-358,共2页
Zhejiang Journal of Traumatic Surgery
